Total bilirubin less than 1.5 x ULN (unless known Gilbert's disease) and AST/ALT less than 3 x ULN
Absolute neutrophil count greater than 1500/mm3
Platelet count greater than 100,000/mm3
Women of childbearing age must have a negative blood pregnancy test
Men and women of childbearing potential must be willing to use effective contraception while on treatment and for at least 3 months there after
You may not be if
Prior chemotherapy or radiation therapy for this lung cancer (history of prior lung cancer that has been treated and deeded inactive by the clinician is acceptable)
Ineligible for cisplatin or carboplatin per medical oncologist
Ineligible for pemetrexed per medical oncologist
Greater than minimal, exudative, or malignant pleural effusion
Calculated creatinine clearance by Cockcroft \& Gault method ≤45 ml/min
Unstable congestive heart failure
Ejection fraction \<50% as assessed by MUGA or echocardiogram
Interstitial lung disease
Patient requiring on-going treatment with a potent inhibitor (cyclosporin, erythromycin, ketoconazole, itraconazole, quinidine, phenobarbital with quinidine, ritonavir, valspodar, verapamil) or inducer of P-gp (St. John's wort or rifampin)
Women who are breastfeeding
Clareo Health | Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation
