Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI

Inclusion Criteria

• •1. Ages 15 - 30 years (inclusive) and able to give voluntary informed consent (parents must also sign consent for subjects under 18)
• •2. Satisfy criteria for Diagnostic and Statistical Manual 4th edition (DSM-IV-TR) for Bipolar I or II disorder
• •3. Satisfy criteria for DSM-IV depressive episode-current
• •4. 17-item Hamilton Depression Rating Scale \> 15 but \< 25;
• •5. Young Mania Rating Scale score \< 10
• •6. Satisfy criteria to undergo an MRI scan based on MRI screening questionnaire.
• •7. Able to be managed as outpatients during the study as ascertained by the following - i. Clinical Global Severity Scale \< 5 i.e. moderately ill; ii. No significant suicidal or homicidal ideation or grossly disabled.
• •1. Ages 15 - 30 years and able to give voluntary informed consent (Parental consent must also be obtained for those under 18 years old).
• •2. Satisfy criteria for DSM-IV-TR Major Depressive Episode using a Structured Interview
• •3. Never met criteria for mania or hypomania
• •4. 17-item Hamilton Depression Rating Scale score (HDRS) \> 15 and \< 25.
• •5. Young Mania Rating Scale (YMRS) score \< 10
• •6. Satisfy safety criteria to undergo an MRI scan
• •7. Able to be managed as outpatients during the study as ascertained by the following - i. Clinical Global Severity Scale \< 5 i.e. moderately ill; ii. No significant suicidal or homicidal ideation or grossly disabled
• •At least one of the following:
• •1. Family history of bipolar disorder in at least one first degree relative
• •2. History of any sub-threshold hypomania symptoms
• •3. History of mood episode related psychotic symptoms
• •1. No family history of BD in a first or a second degree relative
• •2. No past history of any sub-threshold hypomania symptoms
• •3. No history of psychotic symptoms
• •1. Ages 15 - 30 years (inclusive) and able to give voluntary informed consent (Parental consent must also be obtained for those under 18 years old)
• •2. No current or past history of psychiatric illness or substance abuse or dependence.
• •3. No current or past history of psychiatric illness or substance abuse or dependence in a first degree relative.