Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers

Exclusion Criteria

• •Hypertension;
• •Hypotension with symptoms;
• •Coronary heart disease;
• •Lifetime history of heart attack;
• •Cardiac rhythm disorder (irregular heart rhythm);
• •Chest pains (unless history, exam, and electrocardiogram (ECG) clearly indicate a non-cardiac source);
• •Cardiac (heart) disorder (including but not limited to valvular heart disease, heart murmur, heart failure);
• •History of skin allergy;
• •Active skin disorder (e.g., psoriasis) within the last five years;
• •Liver or kidney disorder (except kidney stones, gallstones);
• •Gastrointestinal problems or disease other than gastroesophageal reflux or heartburn;
• •Active ulcers in the past 30 days;
• •Currently symptomatic lung disorder/disease (including but not limited to Chronic obstructive pulmonary disease (COPD), emphysema, and asthma);
• •Brain abnormality (including but not limited to stroke, brain tumor, and seizure disorder);
• •Migraine headaches that occur more frequently than once per week;
• •Recent, unexplained fainting spells;
• •Problems giving blood samples;
• •Diabetes treated with insulin; non-insulin treated diabetes (unless glucose is less than 180mg/dcl and HbA1c is less than 7%);
• •Current cancer or treatment for cancer in the past six months (except basal or squamous cell skin cancer);
• •Other major medical condition;
• •Current psychiatric disease (with the exception of anxiety disorders, Obsessive Compulsive Disorder (OCD) and ADHD);
• •Suicidal ideation (within the past 10 years) or lifetime occurrence of attempted suicide;
• •Current depression;
• •Bulimia or anorexia;
• •Use of opiate medications for pain or sleep (non-opiate medication for pain or sleep will be allowed) within the past 14 days;
• •Smoking more than one cigar a month.
• •Alcohol abuse;
• •Significant adverse reaction to nicotine patches, bupropion / Wellbutrin / Zyban or Chantix / varenicline in the past.
• •Current participation or recent participation (in the past 30 days) in another smoking study at our Center or another research facility.
• •Current participation in another research study.
• •Use (within the past 30 days) of:
• •Illegal drugs (or if the urine drug screen is positive for tetrahydrocannabinol (THC), Cocaine, Amphetamine, Opiates, Methamphetamines, phencyclidine (PCP), Benzodiazepines, or Barbiturates),
• •Experimental (investigational) drugs;
• •Psychiatric medications including antidepressants, anti-psychotics or any other medications that are known to affect smoking cessation (e.g. clonidine);
• •Smokeless tobacco (chewing tobacco, snuff), pipes or e-cigarettes;
• •Wellbutrin, bupropion, Zyban, Chantix, varenicline, nicotine replacement therapy or any other smoking cessation aid.