Sevoflurane- Safety in Long-term Sedation Procedures

Exclusion Criteria

• •Chronic renal failure treated with replacement therapy (hemodialysis or peritoneal dialysis).
• •Acute kidney injury in Stage 3 of AKIN classification
• •Grade C hepatic Child-Pugh classification
• •Established Acute Respiratory Distress Syndrome (ARDS).
• •Central nervous system pathology with cognitive disorders that not allow performing the test of the study: severe dementia, Alzheimer's disease, depression, schizophrenia, acute stroke.
• •Head trauma with Glasgow \<12.
• •Patient treated with antiepileptic drugs that must be maintained during the study period
• •Patients requiring the use of neuromuscular blocking agents during the infusion of study drug, except for the insertion of the endotracheal tube.
• •Epidural or spinal analgesia
• •Allergy or known hypersensitivity to any of the study drugs
• •Patients with known or suspected genetic susceptibility to malignant hyperthermia
• •Previous participation in this trial
• •Participation in another clinical trial within 4 weeks prior to selection.
• •Pregnant women