Lead Sponsor

Duke University

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•LVEF ≤ 35%.
•NYHA class II, III, or IV heart failure for the previous three months despite a minimum of 6 weeks of treatment.
•Must be on optimal heart failure therapy according to AHA/ACC and HFSA heart failure guidelines, including treatment with ACEI and beta-blocker therapy, or have documented rationale for variation, including intolerance, contraindication, patient preference, or personal physician's judgment.

•Age less than 18.
•Currently pregnant or intending to become pregnant in the next year.
•Cardiovascular procedure or hospitalization for any reason planned in the next 6 months.
•Expectation of receiving a cardiac transplant in the next six months.
•Unable to provide the study consent.
•Participation another clinical trial(s) that may interfere with follow-up or data collection for this study, or that may affect cardiovascular mortality.

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