Mechanisms of Interplay Between Allergy and Viruses in Asthma

Exclusion Criteria

• •Smoking history over past 6 months
• •Negative skin prick tests
• •Current symptoms of allergic rhinitis
• •Current or previous history of significant respiratory disease (other than asthma)
• •Any clinically relevant abnormality on screening or detected significant systemic disease
• •Pregnant or breastfeeding women
• •Contact with infants or elderly at home or at work
• •Asthma exacerbation or viral illness within the previous 6 weeks
• •Treatment with oral steroids now or in the previous 3 months
• •Current use of nasal spray, anti-histamine, anti-leukotrienes
• •Antibodies to rhinovirus 16 in a titre \>1:2
• •Any clinically relevant abnormality on screening or detected significant systemic disease
• •A current or previous diagnosis of asthma
• •Any positive skin prick test
• •Current symptoms of allergic rhinitis
• •History of eczema or allergic rhinitis
• •Pregnant or nursing women
• •Common cold within the previous 8 weeks
• •Treatment with oral or inhaled steroids now or in the previous 3 months; current use of long-acting β-agonists, nasal spray, anti-histamine, leukotrienes or tiotropium.
• •Shortness of breath score at screening over 1 or total lower respiratory tract score over 7
• •Antibodies to rhinovirus 16 in a titre \>1:2