Catharina Belge, M.D., Ph. D.

CONTACT

Lead Sponsor

Universitaire Ziekenhuizen KU Leuven

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•male/female ≥ 18 years old
•patient with obstructive sleep apnea (apnea-hypopnea index ≥ 20) naïve for CPAP treatment
•patient with weak or moderate hypertension (140 \<= systolic blood pressure (SBP) \< 180 mmHg and 90 \<= diastolic blood pressure (DBP) \< 110 mmHg naïve for any antihypertensive treatment
•negative pregnancy test
•ambulatory patient
•patient who have signed the informed consent form
•patient affiliated to social security

•pregnant or nursing woman
•acute hepatic failure, biliary cirrhosis, cholestasis
•clearance of Cockcroft \< 30 ml/min/1.73m2
•sick sinus syndrome, including sino-atrial block
•second and third degree heart block (without a pacemaker)
•history of bronchospasm and bronchial asthma
•bradycardia (heart rate\< 60bpm prior to start therapy)
•severe peripheral circulatory disturbances
•acute hypertension (SBP\>= 180 mmHg and/or DBP \>= 110 mmHg)
•severe daytime sleepiness (Epworth rating scale \> 15)
•known cardiovascular pathologies
•contraindication to CPAP
•allergy to nebivolol
•patient treated with antihypertensive drug(s), with class I antiarrhythmics (quinidine, hydroquinidine, cibenzoline, flecainide, disopyramide, lidocaine, mexiletine, propafenone)
•patient treated with CPAP
•patient kept in detention, major protected by the law, hospitalised person
•patient currently participating in another clinical trial

Related studies

NCT05052216 · Pediatric Obstructive Sleep Apnea

NCT07225686 · Obesity, Obstructive Sleep Apnea

NCT07481981 · Pulmonary Arterial Hypertension

NCT07047092 · Chronic Obstructive Pulmonary Disease Exacerbation, Obstructive Sleep Apnea Exacerbation

NCT07606859 · Hypertension Arterial, 65 Years Older

CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.