Oral and IV Baclofen in Adult Volunteers

Exclusion Criteria

• •Subjects will be excluded from participation in the study if any of the following conditions exist:
• •1. Women who are pregnant.
• •2. Women who are breast feeding.
• •3. Subject has a history of intolerance to IV administration of medication.
• •4. Subject has a known hypersensitivity to baclofen.
• •5. Subject has a significant history of cardiac, neurologic, psychiatric, oncologic, endocrine, metabolic, renal or hepatic disease
• •6. Subject has taken or used any investigational drug or device in the 30 days prior to screening.
• •7. Subject has taken either prescribed or over the counter medication for 48 hours prior to baclofen administration on either of the study days.
• •8. Subject reveals clinically significant abnormalities on screening laboratory tests.
• •9. Subject is a non-English speaker, such that ability to ascertain neurological status would require an interpreter.