Diagnosis of multiple sclerosis by a neurologist based on standard criteria (Annals Neurol 2011; 69:292-302)
Expanded Disability Status Scale score of 0 to 7.0
MS-relapse free for \>30 days prior to screening
Pittsburgh sleep quality Index \> 5
Fatigue Severity Scale score \>=4
Montreal Cognitive Assessment (MoCA) \>= 26
diagnosis of OSAH by polysomnography showing AHI \>= 15 events/h of sleep
forced vital capacity \>60% predicted
You may not be if
pregnancy or planned pregnancy
psychiatric conditions which could preclude compliance with informed consent, study procedures, or study requirements
other significant neurological, pulmonary, otorhinological, and medical disorders
major depression within the past year
any value of \>1.5 times the upper limit or \<0.75 the lower limit of the reference range for any standard clinical hemogram and biochemistry determinations which is clinically significant
current treatment for OSAH
presence of another untreated sleep disorder which is clinically significant
very severe OSAH (safety criterion)defined as an AHI \>30 with either a 4% O2 desaturation index \>15 events/h OR work in a safety-critical position OR an ESS score \>=15
Clareo Health | Sleep Apnea in Multiple Sclerosis Positive Airway Pressure Trial
