Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH

Exclusion Criteria

• •1. Co-morbid condition requiring daily administration of a medication that induces hepatic enzymes or interferes with the metabolism of glucocorticoids.
• •2. Clinical or biochemical evidence of hepatic or renal disease. Creatinine above the normal range or elevated liver function tests (ALT or AST) \> 2 times the upper limits of normal.
• •3. Females who are pregnant or lactating.
• •4. Women taking an estrogen-containing oral contraceptive pill and who have taken it within 6 weeks of recruitment.
• •5. Patients taking spironolactone.
• •6. Patients on inhaled or oral steroids apart from treatment for CAH.
• •7. Patients with any other significant medical or psychiatric conditions that in the opinion of the Investigator would preclude participation in the trial.
• •8. Participation in another clinical trial of an investigational or licensed drug or device within the 3 months prior to inclusion in this study.
• •9. Patients with history of bilateral adrenalectomy.