Phase II Study of Neoadjuvant Chemotherapy Regimen Choice in Breast Cancer

Inclusion Criteria

• •Diagnosis of invasive ductal or lobular breast cancer.
• •Previously untreated (no chemotherapy or hormonal therapy or radiation therapy) invasive breast cancer.
• •no anti-Her2 therapy if HER2 positive ( defined as 3+ IHC or FISH positive)
• •Performance Status ECOG \<2
• •Age \> 18 years
• •Tumor \> 2.0 cm by MRI and/or sonographic or clinical exam measurements.or Karnofsky \>50%
• •Lab test :
• •* Absolute neutrophil count \> 1,500/mm3
• •* Total Bilirubin ≤ 2×ULN
• •* AST and ALT ≤ 2.5×ULN
• •* serum creatinine ≤ 1.5×ULN