Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Noblewell
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Resistant HTN criteria with either confirmed sleep disordered breathing. Definition of HTN:Office SBP ≥ 160 mmHg and daytime mean ABPM ≥ 140 mm Hg
Definition of sleep disordered breathing: SDB defined as mild to moderate obstructive, central or mixed sleep apnea defined as 5 \< AHI \< 30 with O2 desaturation not exceeding 80% during the night.
You may not be if
Calculated GFR \< 30
Carotid body located outside the defined carotid septum
Obstructive carotid atherosclerotic disease
Oxygen desaturation at rest below 92%
Known structural lung disease (medical interview)
Requirement for oxygen therapy to maintain oxygen saturation
Patients wish to participate in mountain climbing, skin diving or free diving
Pregnancy or anticipation of pregnancy
Palliative care/chemotherapy
Acute coronary syndrome or unstable angina \< 6 months prior to procedure
Use of exogenous insulin AND history of hypoglycemic unawareness
Stroke or transient ischaemic attack (TIA), or myocardial infarction \< 6 months prior to procedure
Expected life expectancy less that 24months due to other disease
Intravenous drug use
Excessive use of alcohol or sedatives (Alcohol intake \>28 units/week)
Obesity (BMI \> 40)
Upper airway or facial abnormalities
Large neck circumference (\>43.2 cm men; \>40.6 cm women)
Febrile illness within two weeks of participation
Unable to attend for follow up appointments at 1, 3 and 6 months post operatively.
Clareo Health | Carotid Body Removal for the Treatment of Resistant Hypertension: a Pilot Study
