Reperfusion With Cooling in Cerebral Acute Ischemia II

Exclusion Criteria

• •Females of childbearing potential who are pregnant or not using adequate contraception;
• •Bleeding diathesis with a platelet count \< 50,000 or International Normalized Ratio (INR) \>1.5 or any active or recent (within 10 to 30 days) hemorrhage;
• •History of genetically confirmed hypercoagulable syndrome;
• •Any condition that excludes MRI imaging;
• •History of dementia, currently on Aricept or Namenda, or other Alzheimer's like symptoms;
• •End stage renal disease on hemodialysis;
• •History of cardiac arrest;
• •Presence of an inferior vena cava (IVC) filter;
• •Contrast dye allergy with history of anaphylaxis, known serious sensitivity to contrast agents or any condition in which angiography is contraindicated;
• •Known allergy to meperidine or buspar;
• •Sustained hypertension (systolic blood pressure (SBP) \> 185 or diastolic blood pressure (DBP) \> 110 refractory to treatment);
• •Baseline CT/MRI of head showing evidence of mass effect with mid-line shift, hemorrhage, intracranial tumor, arterial vasculitis or dissection, or bilateral stroke;
• •Presence of any other serious comorbidity that would be likely to impact life expectancy to less than 6 months or limit subject cooperation or study compliance;
• •Concurrent participation in an investigational clinical study that has not completed the follow-up period or planned participation in another study within the next 3 months;
• •Subject has any other condition or personal circumstance that, in the judgment of the investigator, might interfere with the collection of complete, good quality data or the completion of the research study