Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Mayo Clinic
With
Alliance for Clinical Trials in Oncology
Participants will need to be scheduled to undergo a surgical resection of their lung cancer at the Mayo Clinic in Rochester, Minnesota. They will be asked to provide a blood sample prior to their surgery. Samples of tumor tissue and normal lung tissue will be taken from the samples removed during your lung surgery. The tissue will be used to evaluate DNA. A skin biopsy at the edge of the incision that has already been made will be done during your surgery. We will take the skin and grow skin fibroblasts. Then we will reprogram the skin fibroblasts into induced pluripotent cells. You will be "randomized" into one of the study groups to either take Metformin for 6 months with your standard of care follow up or to receive standard of care follow up.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Suspected or biopsy proven Stage IA-IIIA lung squamous cell carcinoma (SCC) (must be proven SCC at the time of surgery)
Medically fit for surgical resection (based on surgeon assessment)
Current or prior smoker
Age \> 18 years old
Both Male and Female
Willing and able to consent to study, undergo study interventions, and take study drug
Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, 2
Subject must start Metformin within 90 days of surgery.
You may not be if
Currently taking metformin or other diabetic drugs
Current or previous congestive heart failure, renal failure or liver failure
Creatinine in Women of 1.4 or greater and Creatinine in Men of 1.5 or greater
Existing untreated or prior cancer \<5 years from diagnosis
Received neo-adjuvant platinum-based chemotherapy or targeted therapy
Receiving adjuvant platinum-based chemotherapy or targeted therapy after surgical resection
