Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.

Inclusion Criteria

• •Healthy Volunteers:
• •Age ≥ 18 and \< 50 years No history of allergy, haematological malignancies or immune diseases
• •Subjects with allergy:
• •Children:
• •Age ≥ 4 and \< 18 years Clinical history supporting the diagnosis of severe food allergy Peanut specific IgE (Arah2) -Adults: Age \> 18 and \< 60 years History of severe reaction after antigenic challenge Anaphylactic shock already experienced Specific IgE or positive BAT Positive prick tests
• •subject with HPS:
• •Children:
• •Age ≥ 4 and \< 18 years Henoch Schonlein Purpura (HSP) documented by Ankara 2008 criteria
• •Adult: Henoch Schonlein Purpura(HSP) with renal involvement Adults ≥ 18 years,