Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion

IOP over 30 mm Hg

Any previous retinal laser photocoagulation to the study eye

Previous intravitreal injection in the study eye of any corticosteroid treatment

Previous vitrectomy in study eye (posterior or anterior associated with vitreous loss in cataract surgery)

Intracapsular cataract extraction

Any previous radiation treatments to head/neck that the principal or sub investigator feels is clinically relevant

Inability to assess iris or angle neovascularization (corneal opacity precluding gonioscopy)

Significant cardiovascular disease or cancer that would prevent follow-up visits or completion of the 12 month study

Significant diabetic retinopathy in the fellow eye (diabetic macular edema, proliferative diabetic retinopathy, or high-risk non-proliferative diabetic retinopathy)

Participation in another simultaneous medical investigator or trial

Ocular disorders or concurrent disease in the study eye that may confound interpretation of study results, compromise visual acuity or require medical or surgical intervention, including history of retinal detachment, macular hole, or choroidal neovascularization of any cause (e.g., DME, AMD, ocular histoplasmosis, or pathologic myopia)

Structural damage to the center of the macula in the study eye prior to CRVO, HRVO and BRVO likely to preclude improvement in visual acuity following the resolution of macular edema, including atrophy of the retinal pigment epithelium, subretinal fibrosis, laser scar(s)

Vitreomacular traction or clinically significant epiretinal membrane in the study eye evident biomicroscopically or by OCT (vitreomacular attachment OK)

Infectious blepharitis, keratitis, scleritis, or conjunctivitis (in either eye) or current treatment for serious systemic infection

Spherical equivalent of the refractive error in the study eye of more than -8 diopters myopia (For patients who have had refractive or cataract surgery in the study eye, preoperative spherical equivalent refractive error of more than -8 diopters myopia is not allowed)

Uncontrolled Blood pressure: defined as systolic pressure \> 180mmHg and/or diastolic pressure of \>110 mm Hg (sitting) during the screening period

Uncontrolled diabetes mellitus

Renal failure requiring dialysis or renal transplant

Pregnancy (positive pregnancy test) or lactation

Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an IUD, or contraceptive hormone implant or patch.

History of other disease, metabolic dysfunction, physical examination finding, or other findings giving reasonable suspicion of a disease or condition that contraindicates the use an investigational drug, might affect interpretation of the results of the study, or render the subject at high risk from treatment complications

History of allergy to fluorescein, not amenable to treatment

Inability to obtain fundus photographs or fluorescein angiograms of sufficient quality to be analyzed by the principal investigator (PI) and/or the sub-investigator.

History of allergy to humanized antibodies or any component of the ranibizumab formulation

What this study is about