Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen

Exclusion Criteria

• •Subjects presenting with any of the following will not be included in the trial:
• •1. Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications (e.g. metal in the eye, claustrophobia);
• •2. Unable to receive gas mixture by breathing because of contraindications;
• •3. Participation in a clinical trial with a study drug that may impact lung function in the past 14 days; or
• •4. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
• •5. Female; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.
• •Normal Subjects
• •Subjects presenting with any of the following will not be included in the trial:
• •1. Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications (e.g. metal in the eye, claustrophobia);
• •2. Unable to receive gas mixture by breathing because of contraindications;
• •3. Participation in a clinical trial with a study drug that may impact lung function in the past 14 days; or
• •4. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
• •5. Female; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.