The prevalence of insulin resistance did not significantly differ among the healthy controls and drug-naïve MDD patients before and after antidepressant treatment. Meanwhile, the current study indicated that antidepressants might affect insulin secretion independently of the therapeutic effects on MDD. Therapeutic strategies considering both treatment effectiveness and glucose-insulin homeostasis in MDD patients are necessary.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age: 16-65 years old
Signed informed consent by patient or legal representative
Hamilton Rating Scale for Depression (HDRS) scores ≥ 16
A diagnosis of MDD according to DSM-IV criteria made by a specialist in psychiatry
You may not be if
Monoamine oxidase inhibitor or antidepressant treatment prior to entering the study
A DSM-IV diagnosis of substance abuse within the past three months
An organic mental disease, mental retardation or dementia
A serious surgical condition or physical illness
Patients who were pregnant or breastfeeding
Clareo Health | Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder
