Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD

Exclusion Criteria

• •Hospital admission due to COPD exacerbation or lung infection in the 6 weeks prior to screening, diagnosis of current or previous bronchial asthma, history of allergic rhinitis or other atopic diseases, or peripheral eosinophilia \>400/mm3.
• •Inability to discontinue the usual bronchodilator therapy prior to initial screening tests, need for continuous oxygen therapy, or arterial oxygen saturation \<85% at rest, or history of adverse reactions to sympathomimetic amines or use of inhaled medication.
• •Anemia, hypo- or hyperthyroidism, hyperadrenergic conditions, uncontrolled insulin-dependent diabetes mellitus, malignancy, or any disease or condition that limits exercise capacity other than COPD.
• •History of drug or alcohol abuse, poor adherence to drug treatment, or treatment with any investigational drug in the month before screening.
• •Patients with ventricular arrhythmia.
• •Patients with \<80% oxyhemoglobin saturation during exercise testing