If female, pregnant or lactating

Customary bedtime later than midnight

History of significant medical condition, behavioral, or psychiatric disorder (including suicidal ideation), or surgical history

Any other clinically relevant medical, behavioral or psychiatric disorder other than narcolepsy that is associated with excessive sleepiness

History of significant cardiovascular disease

Body mass index \> 34

Excessive caffeine use - \> 600 mg/day of caffeine or \> 6 cups of coffee/day

History of alcohol or drug abuse within the past 2 years

Nicotine dependence that has an effect on sleep

A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy