Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
This study will examine the role of intravenous lidocaine in the relief of neuropathic pain over four weeks following infusion compared to an active placebo infusion of diphenhydramine(Benadryl) in normal saline. If we can show that intravenous lidocaine provides sustained benefit for up to one month, this will be a major advance in the management of individuals suffering from neuropathic pain.
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Chronic neuropathic pain due to diabetes mellitus or herpes zoster and a score of 4/10 or greater on the DN4 questionnaire.
Moderate to severe pain as defined by screening average pain intensity of 5 or greater on a 0-10 numerical rating scale.
Neuropathic pain duration of at least 6 months.
You may not be if
Presence of clinically significant cardiac disease.
Poorly controlled seizure disorder.
Significant psychiatric disorder.
History of allergy to lidocaine or any other amide local anesthetic
History of allergy to diphenhydramine.
Prior treatment with a local anesthetic infusion.
Neuropathic pain due to cancer or complex regional pain syndrome
Language barrier or cognitive impairment that would preclude understanding of the study and filling out of questionnaires
Lack of a driver to transport the patient to and from the pain clinic.
