Interleukin-1 Trap to Treat Vascular Dysfunction in Chronic Kidney Disease (CKD)

Exclusion Criteria

• •Patients with advanced CKD requiring chronic dialysis
• •Active infection (chronic or acute (within 3 months) or antibiotic therapy (w/in 1 mo); history of recurrent infection
• •Significant co-morbid conditions that lead the investigator to conclude that life expectancy is less than 1 year
• •Expected to undergo living related transplant in next 6 months
• •History of severe congestive heart failure (i.e., EF \< 35%)
• •Hospitalization in the past month
• •Severe arthritis, lupus, inflammatory bowel disease, asthma or other disease(s) or medical condition(s) that, in the opinion of the investigator, could interfere with hsCRP or immune function
• •Immunosuppressant agents such as cyclosporine, tacrolimus, azathioprine, etanercept, infliximab, adalimumab, anakinra or long-term oral glucocorticoids taken in past 12 months
• •Known malignancy
• •HIV, active, chronic hepatitis B as evidenced by HBsAg positive and HBsAb negative, or hepatitis C positive
• •Woman who are pregnant, nursing or planning to become pregnant
• •Body mass index (BMI) \>40 kg/m2
• •Warfarin use (or other cytochrome P (CYP)450 substrates with a narrow therapeutic index) \[ok if do not participate in endothelial cell collection\]
• •Taking medication(s) that interact with agents administered during experimental sessions (e.g., sildenafil interacts with nitroglycerin)
• •Currently receiving or planning to receive live or inactivated vaccines
• •Alcohol dependence or abuse
• •Subjects at risk for tuberculosis (TB). Specifically, subjects with:
• •Current clinical, radiographic or laboratory evidence of active TB at screening or latent TB that has not been previously treated
• •A history of active TB within the last 3 years even if it was treated.
• •A history of active TB greater than 3 years ago unless there is documentation that the prior anti-TB treatment was appropriate in duration and type.
• •Therapy for latent TB which has not been completed as per local guidelines.