Agree not to use prescription medications within 14 days before first administration of study medication and through the duration of the study (with the exception of contraception and hormone replacement therapy (HRT)).
Agree not to use over the counter (OTC) medications (including corticosteroids, decongestants, antihistamines, aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)) and herbal medication (including, but not limited to, herbal tea and St. John's Wort), within 14 days before first administration of study medication and through to the final follow up visit, unless approved by the Investigator and Sponsor Medical Monitor. Occasional use of paracetamol at recommended doses (≤ 1 g/ 6 hours and ≤ 2 g/day) and continued pre-existing use of vitamins at recommended doses is allowed.
You may not be if
Any acute or chronic illness or clinically relevant abnormality identified on the screening medical assessment, laboratory tests or ECG.
Upper or lower respiratory tract infection within 4 weeks of the screening visit.
A positive pre-study hepatitis B surface antigen or positive hepatitis C antibody result at screening.
Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
Positive urinary drugs or breath alcohol test at screening or prior to dosing.
The Investigator suspects drug or alcohol abuse.
A positive test for human immunodeficiency virus antibody.
History of regular alcohol consumption within 6 months of the study.
The subject has participated in any other study of an investigational drug during the 3 months before receipt of the first dose of study medication or has previously received RV568.
Regular use of prescription or non-prescription drugs within 14 days prior to the first dose of study medication.
Allergy to any of the active or inactive ingredients in the study medication.
History of drug, or other allergy that, in the opinion of the Investigator or Sponsor Medical Monitor, would contraindicate their participation.
The subject is a smoker (regular or irregular), or has smoked or used nicotine-containing products within the 6 months prior to screening.
Positive carbon monoxide breath test at the screening visit indicative of smoking or use of tobacco or nicotine-containing products.
Donation of blood in excess of 500 mL within a 3 month period prior to screening, or if study participation would result in blood loss in excess of 500 mL in a 3 month period.
The subject is unable or unwilling to comply fully with the study protocol.
Subject is mentally or legally incapacitated.
Subject is an employee of the Sponsor or contract research organization (CRO), or a relative of an employee of the Sponsor or CRO.
Unable or unwilling to undergo multiple venepuncture procedures or the subject has poor access to veins suitable for cannulation.
A positive pregnancy test or is a lactating (nursing) female.
Any other reason that the Investigator considers makes the subject unsuitable to participate.
