Thyroid Hormone Replacement for Subclinical Hypothyroidism

Exclusion Criteria

• •Subjects currently on Levothyroxine or antithyroid drugs, amiodarone or lithium.
• •Recent thyroid surgery or radio-iodine (within 12 months).
• •Grade IV NYHA heart failure.
• •Prior clinical diagnosis of dementia.
• •Recent hospitalisation for major illness or elective surgery (within 4 weeks).
• •Recent acute coronary syndrome, including myocardial infarction or unstable angina (within 4 weeks).
• •Terminal illness.
• •Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
• •Subjects who are participating in ongoing RCTs of therapeutic interventions (including CTIMPs)
• •Plan to move out of the region in which the trial is being conducted within the next 2 years (proposed minimum follow-up period).