An Exploratory Haemodynamic Study in Patients With Compensated Cirrhosis and Portal Hypertension

Exclusion Criteria

• •Study Parts A and B:
• •Use of any drug to treat portal hypertension (e.g. vasodilators such as non-selective beta blockers or nitrates) within 1 month prior to screening.
• •Decompensated cirrhosis (Child-Pugh score \>9 points, and/or ascites requiring diuretics, and/or hepatic encephalopathy) at visit 1.
• •Presence of any non-controlled and clinically significant disease that could affect the study outcome or that would place the patient at undue risk.
• •Part A:
• •BMI (weight\[kg\] / height\[m\^2\]) \> 40 kg/m\^2.
• •Any contraindication to having an MRI scan
• •Part B:
• •Contraindication to catheterization