The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin

Exclusion Criteria

• •1. Infections and other minor addition of erysipelas / cellulitis
• •2. Any recent use of antibacterial drug therapy (systemic or topical antibacterial drugs within 14 days of enrollment)
• •3. Patients with clinical conditions that alter the interpretation of the primary outcome as patients with neutropenia or compromised immune function, as HIV infection, autoimmune disorders, use of corticosteroids.
• •4. Patients with known or suspected osteomyelitis.
• •5. Patients with suspected or confirmed septic arthritis.
• •6. Patients with complicated skin infections, such as diabetic foot infections. 7. Chronic use of antipyretic drugs (eg, daily use of naproxen).
• •8\. Less than 18 years of age. 9. pregnancy 10. Patients with mixed infections of Gram-negative or be deleted since the therapy of gram-negative can influence the levels of cytokines.
• •11\. Patients with renal clearance \<30 mL / min. 12. Patients who are not susceptible to daptomycin or vancomycin. 13. Allergy to study medication.