A Study Measuring Effect of LY2140023 (Pomaglumetad Methionil) on Electrocardiographs in Participants With Schizophrenia

Exclusion Criteria

• •Currently enrolled in, have completed or have discontinued from a clinical trial involving an investigational drug within the last 30 days
• •Known allergies to pomaglumetad methionil (LY2140023) or its active metabolite (LY404039), moxifloxacin, related compounds, or components
• •Previously completed this study or prematurely discontinued from any study after having received at least 1 dose of pomaglumetad methionil (LY2140023)
• •Received treatment with clozapine
• •Received aripiprazole within 2 months prior to screening
• •Taking either thioridazine or thiothixene
• •Receiving treatment with depot antipsychotic medication within 12 weeks, prior to screening
• •Taking any medications other than those that are specifically permitted in the protocol
• •Asthma needing active beta 2 (B2) agonist within 14 days of the study
• •Active suicidal ideation with some intent to act, without specific plan or with specific plan and intent or had suicidal behavior such as actual attempt, interrupted attempt, aborted attempt, preparatory act, or behavior within the past 3 months
• •Substance dependence or substance abuse (except nicotine and caffeine) within the 6 months prior to admission
• •Substance-induced psychosis within 7 days of admission (or at any time during the dosing period)
• •History of 1 or more seizures (with exceptions)
• •Screening electroencephalogram (EEG) with paroxysmal (epileptiform) activity
• •Have had electroconvulsive therapy (ECT) within 3 months of Day 1 of the study or who are expected to have ECT at any time during the live phase of this study
• •Parkinson's disease, dementia-related psychosis, or related disorders
• •Untreated hyperthyroidism or hypothyroidism needing a thyroid hormone supplement who have not been on a stable dose of medication for at least 2 months prior to screening
• •History of leukopenia or agranulocytosis
• •Alanine aminotransferase/serum glutamic pyruvic transaminase (ALT/SGPT) or aspartate aminotransferase/serum glutamic oxaloacetic transaminase (AST/SGOT) values greater than 2 times the upper limit of normal (ULN) or total bilirubin values greater than 1.5 times the ULN of the performing laboratory at screening
• •Abnormality in the 12-lead electrocardiogram (ECG) that increases the risks associated with participating in the study
• •Premature ventricular contraction (PVC) associated with symptoms and/or any complex PVCs
• •Heart rhythm disturbance by history or ECG at screening
• •Personal or family history of long QT wave syndrome
• •Family history of sudden unexplained death or cardiac death in a family member under 60 years of age
• •Unexplained syncope within the last year
• •Acute, serious, or unstable medical conditions
• •Prolactin level of greater than 200 nanograms per milliliter (ng/mL) (200 micrograms per liter \[ug/L\] or 4228 milli-international units per liter \[mIU/L\]) at screening (with the exception of participants treated with risperidone) at screening
• •Medical history of Human Immunodeficiency Virus positive (HIV+) status
• •Test positive for (1) Hepatitis C virus antibody or (2) Hepatitis B surface antigen (HBsAg) with or without positive Hepatitis B core total antibody
• •Smoke greater than or equal to 40 cigarettes per day
• •Movement disorder that could interfere with conducting 12-lead ECGs