Patients with prior fistulotomy, fistulectomy, LIFT, cutting seton or advancement flap procedure

Fistula with multiple tracts

Recto-vaginal fistula

Active infection in the anal fistula

Physical allergies or cultural objections to porcine products

Patient is not medically fit to undergo the LIFT procedure as judged by the treating physician

Previous diagnosis of collagen disorder

History of Crohn's Disease, Irritable Bowel Syndrome, radiation therapy in the rectoanal region

Ligation of the Intersphincteric Fistula Tract (LIFT) + Biodesign for Anal Fistula