Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment

Exclusion Criteria

• •All Individuals
• •A past medical history of clinically significant ECG abnormalities or a family history of a prolonged QT-interval syndrome.
• •Female subjects must be of non child bearing potential or use an effective method of contraception.
• •Individuals with hepatic impairment
• •History of drug or alcohol abuse within 3 months prior to dosing.
• •History or presence of significant uncontrolled disease of any major organ class.
• •Any surgical or medical condition other than hepatic impairment which might alter the drug metabolism.
• •Healthy subjects
• •History or presence of significant uncontrolled disease of any major organ class.
• •Any surgical or medical condition other than hepatic impairment which might alter the drug metabolism.
• •History or presence of hepatitis B or C and/or positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result at screening.