Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis

Exclusion Criteria

• •Patients likely to undergo liver transplantation during the duration of the study.
• •Presence of advanced hepatic encephalopathy Grades 3 \& 4 (West Haven criteria for grading of hepatic encephalopathy) at the time of screening
• •Active variceal bleed.
• •Refractory ascites.
• •Evidences of autoimmune liver disease- ANA or Anti-LKM positivity.
• •Platelet count \< 30,000/mm3.
• •Serum Sodium \<129mEq/L.
• •Serum Creatinine \> 2 mg/dl.
• •Hepatocellular carcinoma or other malignancies
• •Active infectious disease.
• •Presence of severe underlying cardiac, pulmonary or renal disease.
• •Excessive alcohol (\>30 gm of alcohol/day) use in the last 3 months before screening.
• •Positive HbSAg or antibodies to HIV or HCV.
• •Pregnancy or lactation.
• •Participation in other clinical trials.
• •Unwilling/unable to sign the informed consent.