Acute Effect of Exenatide on Brain Glucose Metabolism

Inclusion Criteria

• •1. Males age 18-65 years old
• •2. Patients must have Body Mass Index (BMI) between 25 and 40 kg/m2
• •3. 2-hour glucose concentration above 140mg/dl after 75g glucose load, ie, having impaired glucose tolerance or newly diagnosed type 2 diabetes.
• •4. Patients must have BMI of 25-40 kg/m2
• •5. Patients must have no known severe liver or kidney disease, cancer, neurologic, psychiatric or systemic disease, ability to understand the study.
• •6. Only patients whose body weight has been stable (±3-4 pounds) over the three months prior to study will be included.
• •7. Patients must have the following laboratory values:
• •* Hematocrit ≥ 34 vol%
• •* Serum creatinine\* ≤ 1.5 mg/dl in males and
• •* Aspartate aminotransferase (AST) serum glutamic oxaloacetic transaminase (SGOT): ≤ 2.5 times upper limit of normal
• •* Alanine aminotransferase (ALT) serum glutamic pyruvic transaminase (SGPT): ≤ 2.5 times upper limit of normal
• •* Alkaline phosphatase ≤ 2.5 times upper limit of normal
• •* If serum creatinine is ≤ 1.5 mg/dl in males, the PI can grant an exception and not exclude the patient if the Glomerular filtration rate (GFR) is \>70 ml/min