Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Office of Research and Development
Diabetic chronic kidney disease (CKD) is a common problem in Veterans and progresses to end-stage renal disease in many people. It is important to identify treatment strategies that will help prevent the progression of CKD to overt kidney failure. The purpose of this study is to see if sodium bicarbonate reduces urinary markers of kidney damage in Veterans with diabetic CKD and normal serum bicarbonate levels.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Veteran
Age older than 18 years
Diabetes mellitus
Serum bicarbonate 22 - 28 mmol/L on the most recent measurement within the past six months
Stage 2, 3, or 4 CKD (defined as estimated glomerular filtration rate (eGFR) 15 - 89 ml/min/1.73m2 using the CKD-Epidemiology equation)
Urinary albumin:creatinine ratio \> 30 mg/gm on the most recent sample within the past 12 months.
You may not be if
Lean body weight \> 100 kg
Use of oral medications typically prescribed to raise low serum bicarbonate levels (i.e. sodium bicarbonate, sodium citrate, potassium citrate).
Serum potassium \< 3.5 meq/L at enrollment visit
Use of 5 or more antihypertensive agents, regardless of the indications of each agent
Systolic blood pressure \> 140 mmHg or diastolic blood pressure \> 90 mmHg at the enrollment or baseline visit
Diagnosis of congestive heart failure with current, active Class III or IV New York Heart Association symptoms.
Significant fluid overload such that it is unsafe in the opinion of the PI for the patient to participate in the trial
chronic gastrointestinal disorder or any other factors judged to be likely to limit adherence to interventions (i.e. alcoholism, a history of missing clinic visits)
Chronic immunosuppressive therapy for transplanted organs or other indications
Individuals who are currently a member of a vulnerable population (I.e. incarcerated, pregnant).
11.Currently participating in another interventional research study
Clareo Health | Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
