histologically confirmed adenocarcinoma in colorectal cancer

clinical stage Ⅲ or Ⅳa(with potential radical resective metastatic lesions),≥ 12 lymph nodes examined

no cancer cells were found in ascites

Eastern Cooperative Oncology Group(ECOG) performance status of 0-2

male or female, between 18 and 75 years old

adequate hematologic, hepatic and renal functions

without severe heart disease in the last 6 months before enrolled. If with hypertension or coronary artery disease, it can be controlled

not enrolled into others clinical trial during this study

all patients should sign the informed consent

FOLFIRI or mFOLFOX6 in Adjuvant Chemotherapy in Advanced Colorectal Cancer