Microvascular Blood Flow in Sickle Cell Anemia

Exclusion Criteria

• •Hospitalization, emergency department visit or self-reported crisis within last 2 weeks for any reason or 4 weeks from acute chest syndrome
• •Current physician diagnosis of active asthma (within last 12 months) or current use of asthma medications
• •Second or third degree AV block or sinus node dysfunction
• •Known or suspected right to left sided cardiac shunts
• •History of a bleeding diathesis
• •History of clinically overt stroke
• •History of severe hypertension not adequately controlled with anti-hypertensive medications
• •Receiving chronic anti-coagulation or anti-platelet therapy
• •History of metastatic cancer
• •Receiving other investigational study agents, or have received a study agent in the last 30 days
• •Uncontrolled intercurrent illness
• •Pregnant or breastfeeding women
• •Subjects who have a HIV infection
• •Subjects who have had a hematopoietic stem cell transplant
• •Subjects who are taking medications that may interact with the investigational agent
• •Prior hypersensitivity reactions to either regadenoson or ultrasound contrast agents
• •Hospitalization, emergency department visit or self-reported crisis within last 2 weeks for any reason or 4 weeks from acute chest syndrome
• •Known pregnancy
• •Known history of HIV
• •Known or suspected right to left sided cardiac shunts
• •Receiving other investigational study agents, or have received a study agent within the last 30 days
• •Subjects who have had a hematopoietic stem cell transplant
• •Prior hypersensitivity reactions to ultrasound contrast agents
• •History of severe hypertension not adequately controlled with anti-hypertensive medications
• •Uncontrolled intercurrent illness
• •Pregnant women
• •Subjects who have a HIV infection
• •History of stem cell transplant
• •Current involvement in a therapeutic clinical trial
• •Known or suspected right to left sided cardiac shunts
• •Prior hypersensitivity reactions to ultrasound contrast agents
• •History of severe hypertension not adequately controlled with anti-hypertensive medications
• •Uncontrolled intercurrent illness
• •Sickle cell disease or sickle cell trait
• •Known or suspected right to left sided cardiac shunts
• •Diagnosis of type 1 or type 2 diabetes mellitus
• •Hypertension
• •History or current diagnosis of dyslipidemia or taking lipid lowering drugs
• •Diagnosis of coronary artery disease or peripheral vascular disease
• •Body weight greater than 10% of ideal weight
• •Uncontrolled intercurrent illness
• •Pregnant or breastfeeding women
• •Subjects who have a HIV infection
• •Prior hypersensitivity reactions to ultrasound contrast agents
• •Known sickle cell disease or sickle cell trait
• •Known or suspected right to left sided cardiac shunts
• •Uncontrolled intercurrent illness
• •Known pregnant or breastfeeding women
• •Prior hypersensitivity reactions to ultrasound contrast agents