A Study of ARRY-502 in Patients With Persistent Asthma

Exclusion Criteria

• •Evidence of aspirin-sensitive asthma.
• •Pre-existing lung disease other than asthma.
• •Clinically significant dermatologic, hematological, renal, endocrine, pulmonary (other than asthma), gastrointestinal, cardiovascular, hepatic, neurologic, ophthalmologic, musculoskeletal or immunologic disease (excepting allergic disease and asthma) that is uncontrolled despite treatment or is likely in the opinion of the Investigator to require a change in therapy during the study.
• •Patients with any current or past history of cancer within 5 years prior to study start except for treated basal cell or squamous cell carcinomas of the skin, ductal carcinoma in situ of the breast or cervical carcinomas in situ.
• •Any history of serious illness requiring hospitalization within 6 months prior to study start.
• •Known positive serology for the human immunodeficiency virus (HIV), hepatitis B and/or active hepatitis C.
• •A positive test for drugs or alcohol, unless the positive drug screen is associated with a prescribed medication and is approved by the Medical Monitor.
• •Smoking (tobacco or marijuana) within 6 months prior to study start and/or a smoking history of \> 10 packs/year.
• •Blood donation of ≥ 1 pint (473 mL) within 8 weeks prior to the first dose of study drug.
• •Previous treatment with ARRY-502.
• •Additional criteria exist.