A Human Trial to Assess the Low Density Lipoprotein Cholesterol (LDL-C) Lowering Effect of Soy

Exclusion Criteria

• •Fasting plasma triglycerides ≥4.0 mmol/L
• •Abnormal liver and kidney function
• •Unstable body weight(\>3kg change in 3 months) or intention to lose or gain weight;
• •Diabetes mellitus (fasting plasma glucose ≥7.0 mmol/L or use of insulin or any hypoglycemic or anti-hyperglycemic medication);
• •Use of any prescription or non-prescription drug, prebiotics or probiotics, herbal or nutritional supplement known to affect blood lipids, except for stable doses (no change in 3 months) of thyroxine, oral contraceptive agents, hormone replacement therapy, and medications for controlling blood pressure);
• •Major surgical or medical events within the past 3 months;
• •Presence of a gastrointestinal disorder or medication that alters the digestion and absorption of nutrients; including antibiotic use within the past 6 weeks.
• •Consumption of a diet containing ≥15% of energy from saturated fat;
• •Any food allergy or aversion or unwillingness to eat wheat, soy or milk;
• •Consumption of ≥5 servings per week of soy based food products;
• •Consumption of an average of \>2 alcoholic beverages per day;
• •Regular smokers (smoking ≥1 cigarette per day) of cigarettes or cigars