Present use of drugs for bipolar depression or any psychotropic medication

Use of psychoactive medication that may affect brain imaging findings

Diagnosis of any other axis I psychiatric disorder

Presence of borderline personality disorder or antisocial personality disorder

Presence of any major physical or neurological illness (e.g., epilepsy, multiple sclerosis, brain tumor, cerebrovascular disease, etc.)

Hypersensitivity to divalproate, valpromide or diagnosis of porphyria

Past or current liver disease, current severe liver or pancreas dysfunction

Currently taking mefloquine

Presence of alcohol or drug dependence, drug abuse

Intelligence quotient below 80

Contraindications to magnetic resonance imaging

Women who are pregnant, breastfeeding, or planning pregnancy

Allergy or intolerance to the study drugs

Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression