Do Furanocoumarins Mediate the Fexofenadine-grapefruit Juice Interaction?

Exclusion Criteria

• •History of intolerance to grapefruit products
• •History of any allergy or hypersensitivity to grapefruit products or fexofenadine
• •History of significant medical conditions that the study physician believes would increase risk
• •History of significant alcohol abuse and/or illicit drug use
• •Tobacco use within the month preceding the study
• •Pregnancy or breast-feeding
• •Taking concomitant medications, both prescription and non-prescription (including herbal products), known to alter fexofenadine blood levels or P-gp and/or OATP activity (women stabilized on hormonal methods of birth control will be allowed to participate)