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UNKNOWNNANCT01520974

Effect of an Oral Probiotic Tablet on Oral Bacteria and Clinical Measurements (ProBiora3)

The purpose of this study is to determine if an oral probiotic tablet taken once a day for twelve weeks can decrease the numbers of bacteria that are associated with tooth decay and gum disease in a d...

Lead sponsor: Oragenics, Inc.•1 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Marilynn Rothen, RDH, MS

CONTACT

206-685-8132 [email protected]

Mary K Hagstrom, CDA

CONTACT

206-685-8132 [email protected]

Sponsors

Lead Sponsor

Oragenics, Inc.

Collaborators

University of Washington

There are over 500 types of bacteria in the mouth. Most of these bacteria do not cause disease. However, some mouth bacteria can cause tooth decay and gum disease. The purpose of a probiotic tablet for the mouth is to put known healthy bacteria in the mouth. This study will compare the effect of the probiotic tablet on the levels of harmful or disease causing bacteria in the mouth to a placebo tablet that does not contain any probiotic bacteria.

Age

18 - 35 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•minimum of 20 teeth, with only a few fillings
•good general health
•willing to use an appropriate method of birth control during the study
•measurable levels of Streptococcus mutans and one or more of the selected periodontal pathogens

Exclusion Criteria

•chronic or acute illness such as heart disease, diabetes, cancer, hepatitis (liver disease) or HIV positive
•radiation therapy or systemic cancer treatment (chemotherapy)
•require antibiotics for dental treatment
•pregnant or planning to become pregnant during the study period

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 2, 2012Terms

Trial snapshot

StatusUNKNOWN

PhaseNA

Enrollment48

Start dateJan 2012

Last updatedMay 2, 2012

Condition

Locations shown

University of Washington, Scool of Dentistry, Regional Clinical Dental Research Center

Seattle, Washington

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 2, 2012Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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