Phase II Axitinib (AG-013736) in Elderly Glioblastoma Multiforme (GBM) Patients

Inclusion Criteria

• •Newly diagnosed patients with histologically proven glioblastoma multiforme
• •Age above 70 years
• •Karnofsky score of 50-80
• •Adequate organ function as defined by laboratory values
• •Life expectancy of \>12 weeks
• •No evidence of preexisting uncontrolled hypertension as documented by 2 baseline blood pressure readings taken at least 1 hour apart. The baseline systolic blood pressure readings must be 140 mm Hg, and the baseline diastolic blood pressure readings must be 90 mm Hg. Patients whose hypertension is controlled by antihypertensive therapies are eligible.