REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)

Inclusion Criteria

• •Type 1 Diabetes for five years or more\*
• •Age 40 years or above
• •7.0 =\< HbA1c \<10.0% (53 - 86 mmol/mol)
• •AND 3 or more of the following ten CardioVascular Disease (CVD) risk factors:
• •BMI \>27 kg/m\^2
• •Current HbA1c \>8.0% (64 mmol/mol)
• •Known CVD/peripheral vascular disease
• •Current smoker
• •Estimated glomerular filtration rate (eGFR) \<90 ml/min per 1.73 m\^3
• •Confirmed micro- or macroalbuminuria \[according to local assays and reference ranges\]
• •Hypertension (BP \>=140/90 millimeters of mercury (mmHg) or established on antihypertensive treatment)
• •Dyslipidaemia \[total cholesterol \>=5.0 mmol/L (200 mg/dL);OR HDL cholesterol \<1.20 mmol/L (46mg/dL) \[MEN\]; OR \<1.30 mmol/L (50 mg/dL) \[WOMEN\]; or triglycerides \>=1.7 mmol/L (150mg/dL); or established on lipid-lowering treatment)\]
• •Strong family history of CVD (at least one parent, biological aunt/ uncle, or sibling with myocardial infarction or stroke aged \<60 years)
• •Duration of diabetes \> 20 years