Denervation of the REnal Artery in Metabolic Syndrome

Objectives: The objectives of this study are: to compare changes in insulin resistance in patients with ORH after RDN; to evaluate the safety of PRDN in this patient group; to compare changes in blood pressure, laboratory parameters, arterial stiffness and SNS-activity after PRDN. Study design: Prospective observational feasibility-study. Study population: Patients with a high fasting glucose (fasting serum glucose ≥5.6 mmol/L(100 mg/dL)) and with an ambulatory systolic blood pressure \>130mmHg. Major endpoints: The effect of RDN on: insulin resistance, blood pressure and major adverse events.