Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Health Network, Toronto
Age
18–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Aged 18-70 years old
Performance Status (PS) of 0-1 on the ECOG Performance Scale
Life expectancy of at least 12 months
Full recovery from any post operative sequelae
Adequate hepatic function as documented by a serum bilirubin \< 18umol/L, and LFTs within 1.5X normal range
Patients with histologically confirmed, stage B or C colorectal cancer (CRC), who have undergone surgical resection and are about to commence chemotherapy.
Patients due to receive neoadjuvant chemotherapy prior to surgery are also eligible.
You may not be if
Any major pre-existing psychiatric history or dementia, alcohol abuse, or currently using a psychotropic medication that might lead to cognitive problems, other than short acting benzodiazepines for nausea or sleep
Any evidence of metastatic disease. If there is clinical suspicion of CNS involvement patients must have brain imaging (MRI or CT scan) prior to recruitment.
Ongoing sepsis or uncontrolled infection, including HIV infection
Pre-existing neurological condition likely to interfere with ability to perform cognitive testing
Any other severe co-morbidity which, in the judgement of the investigator, would make the patient inappropriate for entry into this study
Active cancer within the last 5 years other than squamous or basal cell carcinoma of the skin or cervical cancer in situ (except for CRC)
Previous history of chemotherapy
Minimal English skills such that subjects would be unable to follow simple, written English instructions and to read questionnaires of a grade 8 standard with the help of a research assistant.
