Resveratrol-enriched Grape Extract (Stilvid) in Primary and Secondary Prevention of Cardiovascular Disease

Inclusion Criteria

• •FOR PRIMARY PREVENTION:
• •Lack of known cardiovascular disease (coronary acute syndrome, stable ischemic cardiopathy, peripheric arteriopathy and cerebrovascular diseases).
• •Age between 18 and 80 years.
• •The above criteria and diabetes mellitus or at least two of the following risk factors:
• •1. Active smoking (10 cigarettes or more per day).
• •2. Arterial hypertension (\>= 140/90 mmHg).
• •3. Hypercholesterolemia (LDL-cholesterol \>130 mg/dL and/or HDL-cholesterol \< 45 mg/dL in women and 50 mg/dL in men).
• •4. Obesity (BMI \> 30 kg/m2)
• •FOR SECONDARY PREVENTION:
• •Stable patients who coronary syndrome, cerebrovascular accident or peripheric arteriopathy event occurred at least 6 months or more before the recruitment in the study. In addition:
• •1. Age between 18 and 80 years.
• •2. Ejection fraction of left ventricle \>=45%.
• •3. Functional status I or II according to the New York Heart Association.
• •4. Clinic stability in the recruitment (no symptoms of thoracic pain during the last month).
• •5. Lack of residual lesions without vascularization in those patients with catheterism.
• •1. Known allergy to grapes
• •2. Pregnancy or lactation
• •3. Intake of nutraceuticals