AST and ALT \< 2.5 x the upper normal limits (\< 5 x the upper normal limit in the presence of hepatic metastasis)
Bilirubin \< 1.5 x the upper normal limit
Signed informed consent
You may not be if
Previous chemotherapy for advanced disease
History of malignant neoplasm within the previous 5 years (not including non-melanoma skin carcinoma and in-situ carcinoma of the uterine cervix, provided they are being adequately treated)
Symptomatic cerebral or spinal cord metastasis
Myocardial infarct within the last 12 months
Systemic disease not controlled with treatment (active infection, cardiovascular, hepatic, renal or metabolic) that would not, in the opinion of the investigator, permit the patient to undergo chemotherapy.
Known or suspected hypersensitivity to any of the drugs used in the study
Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or give informed consent
