Patient with a metastatic colorectal cancer proved histologically and treated with bevacizumab in first line.

At least one extra-osseous, non-irradiated, measurable site (\>= 10 mm with spiral CT).

No prior radiotherapy treatment unless treatment is over for at least 4 weeks.

Adult patients.

PS \<= 2.

Life expectancy greater than 3 months.

Mandatory affiliation with a healthy security insurance.

Signed written informed consent.

Exploration of Circulating VE-cadherin in Metastatic Colorectal Adenocarcinoma Patients Treated With Bevacizumab