Efficacy and Tolerability of Symbicort as an add-on Treatment to Spiriva Compare With Spiriva Alone in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD)

Exclusion Criteria

• •A history of asthma and seasonal allergic rhinitis before 40 years of age
• •Patients who have experienced exacerbation of COPD requiring hospitalisation and /or emergency room treatment and/or a course of oral steroids and/or intravenous corticosteroids and/or antibiotics within 4 weeks prior to Visit 2 and/or during run-in period and also the patients who use of systemic glucocorticosteroids (GCS) within 4 weeks and/or inhaled GCS within 2 weeks prior to Visit 2 and/or during run-in period
• •Patients with relevant cardiovascular disorder judged by the investigator
• •Patients with glaucoma, prostatic hyperplasia or bladder-neck obstruction judged by the investigator
• •Women who are pregnant, breast-feeding or of child-bearing potential judged by the investigator