Abiraterone Acetate Combined With Dutasteride for Metastatic Castrate Resistant Prostate Cancer

Exclusion Criteria

• •Uncontrolled intercurrent illness
• •Uncontrolled hypertension
• •Active or symptomatic viral hepatitis or chronic liver disease
• •History of pituitary or adrenal dysfunction
• •Clinically significant heart disease
• •History of a different malignancy unless disease-free for at least 5 years
• •Known brain metastasis
• •History of gastrointestinal disorders
• •Prior therapy with abiraterone acetate
• •HIV-positive individuals on antiretroviral therapy
• •Requirement for steroid use greater than the equivalent of 5 mg of prednisone daily
• •Atrial fibrillation or other cardiac arrhythmia requiring therapy
• •Thromboembolism in the last 6 months