Effect of Fimasartan for Modification of Atheroma Vulnerability in DEFERred Coronary Disease (FIMA-DEFER)

Exclusion Criteria

• •1. Planned cardiac surgery (e.g., CABG, valve repair or replacement, or aneurysmectomy) or planned major non-cardiac surgery within the study period
• •2. Planned performance of PCI or CABG in the target vessel or its branches containing the index
• •3. Evidence of congestive heart failure, or left ventricular ejection fraction \< 40%
• •4. Stroke or resuscitated sudden death in the past 6 months
• •5. Chronic disease requiring treatment with oral, intravenous, or intra-articular corticosteroids (use of topical, inhaled, or nasal corticosteroids is permissible)
• •6. A diagnosis of cancer (other than superficial squamous or basal cell skin cancer) in the past 3 years or current treatment for the active cancer
• •7. Any clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the Investigator, would preclude safe completion of the study
• •8. Significant renal disease manifested by serum creatinine \> 1.5 mg/dL
• •9. Hepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation (ALT or AST \> 3 times upper limit of normal)
• •10. Active hepatitis B or C or carrier
• •11. Hypotension (systolic blood pressure \<90 mmHg)
• •12. Patients already taking ACE inhibitors or ARBs
• •13. Patients with STEMI requiring primary PCI
• •14. Patients pregnant or breast-feeding or child-bearing potential
• •15. Patients who are lack of intention for effective contraception
• •16. Patients with history of previous enrollment into a clinical trials within 3 months
• •17. Allergic or contraindicated to Angiotensin II antagonists
• •18. History of any arterial bypass or angioplastic intervention involving the target vessel
• •19. Luminal narrowing in the left main \> 50% by visual inspection of angiogram
• •20. Visually-estimated angiographic reference segment diameter of \<2.75mm or \>4.0 mm
• •21. Presence of thrombus or complex plaque morphology in the target vessel that suggests a high likelihood of distal embolism
• •22. Severe tortuosity of the target vessel or any other anatomical reasons that the investigator deems
• •23. Inappropriate for IVUS procedures. Vessel with thrombus (on GS-IVUS), moderate or severe calcification, angulation
• •24. Culprit vessel in AMI
• •25. RWMA (Regional Wall Motion Abnormality) or scar tissue in the territory subtended by the studied lesion