Simvastatin Treatment of Pachyonychia Congenita

Exclusion Criteria

• •The use of concomitant medications known to interact with simvastatin.
• •This would include itraconazole, ketoconazole, fluconazole, gemfibrozil, verapamil, diltiazem, mibefradil, erythromycin, clarithromycin, telithromycin, cyclosporine, ritonavir, nefazodone, danazol, amiodarone, Rifampin, and carbamazepine.
• •During the study subjects must agree to avoid grapefruit juice.
• •Also excluded are patients with a past history of myopathy, or impaired liver function.